Lorenzo Cenci

Ritratto Lorenzo Cenci

Neuroscience, Technology, and Society, XXXV series
Grant sponsor

Gianluca Mech S.P.A.

Antonio Paoli

Alessandro Sperduti

Project description
Ketogenic diets are characterized by a reduction in carbohydrates and a relative increase in the proportions of protein and fat. Our first goal will be to identify exactly the keto-adapted state with some physiological tests and psychological questionnaires. Then, we will investigate the meantime from the beginning of a VLCKD to the keto-adapted state and the variables that could influence this duration such as different VLCKDs, % of CHO, use of Ketone esters, inter-individual differences (gender, overweight or obese, metabolic characteristics). Lastly, we will verify the effects of a VLCKD on “omics” and how certain omics features might influence time to keto-adaptation. This project will involve many research areas: nutritional, physiology, and computer sciences and we need to integrate all data and develop innovative digital tools to help the formulation of a correct diet to achieve these goals:
1. Development of nutritional protocols that allow to clearly determine the time to keto-adaptation in different subjects.
2. Development of new tools (supplements, ketone esters, MTC oil) that could speed up keto-adaptation.
3. Identification of -omics changes during different protocols of VLCKDs and define the relationship between keto induction and -omics.